PD61-10 BASELINE PREOPERATIVE COMORBIDITY ILLNESS BURDEN AND CALCULATED FREE TESTOSTERONE ASSOCIATION WITH SEXUAL FUNCTION IN PROSTATE CANCER

You have accessJournal of UrologyProstate Cancer: Localized: Surgical Therapy V (PD61)1 Sep 2021PD61-10 BASELINE PREOPERATIVE COMORBIDITY ILLNESS BURDEN AND CALCULATED FREE TESTOSTERONE ASSOCIATION WITH SEXUAL FUNCTION IN PROSTATE CANCER Edward J Choi, Linda Huynh, Farouk el Khatib, Raymond Carillo Ceja, Maxwell Towe, Erica Huang, Faysal Yafi, and Thomas Ahlering ChoiEdward Choi More articles by this author , HuynhLinda Huynh KhatibFarouk Khatib CejaRaymond Ceja ToweMaxwell Towe HuangErica Huang YafiFaysal Yafi AhleringThomas View All Author Informationhttps://doi.org/10.1097/JU.0000000000002098.10AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract INTRODUCTION OBJECTIVE: In men with prostate cancer (PCa), comorbid disease exacerbates poor sexual function. Our group had previously found that calculated free testosterone (cFT), rather than total (TT), was significantly associated function in >60-years age. study, we seek determine whether effect is consistent or independent differing burden between younger older PCa. METHODS: 733 men’s baseline function, cFT, comorbidities were assessed prior surgery, March 2010 - September 2019. Patients stratified age (<60 >60-years) covariates age, identified using two-tailed, Student t-tests. Preoperative as a continuous variable via the International Index Erectile Function (IIEF-5). A modified Charlson Comorbidity (mCCI) stripped age-weighted domain burden. Hypertension (HTN), which not included CCI, separate categorical variable. Two linear regression models cFT predictive after stratifying for significant covariates. RESULTS: Men over 60 years higher mCCI score weight, but lower cFT. Additionally, proportion these also high-risk (GGG 4-5) high-volume (p-stage T3/T4) (Table 1).After adjusting regression, (B: 0.34, 95% CI: 0.07 – 0.61, p=0.014), -1.84, -2.61 -1.07, p <0.001), HTN -2.19, -3.58 -0.80, p=0.002) predictors preoperative IIEF-5 scores above years. GGG 4-5 covariate -0.69, -1.30 -0.07, p=0.030). CONCLUSIONS: Low increased mCCI, reduced ( PCa compared less Source Funding: Self-Funded © 2021 American Urological Association Education Research, Inc.FiguresReferencesRelatedDetails Volume 206Issue Supplement 3September 2021Page: e1070-e1070 Advertisement Copyright & Permissions© Inc.MetricsAuthor Information Expand Loading ...